Idra-21 Púdar cognaíochais rialtóir allosteric dearfach é de receptor AMPA agus díorthach benzothiadiazole. Is móilín ciriúil é ina bhfuil ( móide ) - IDRA-21 an fhoirm ghníomhach.
Conas a d’iompair IDRA-21 i dturgnaimh ainmhithe?
Sa staidéar ar chur chun cinn na hintleachta in ainmhithe,Púdar IDRA-21feabhas suntasach ar chumas na foghlama agus na cuimhne. Chun easnaimh chognaíoch a aisiompú de bharr -úsáid fhadtéarmach alprazolam nó scopolamine, tá sé thart ar 10-30 uair níos láidre ná aniracetam. Is é an rud is iontach ná a chuid ama meitibileachta drugaí: rinneadh staidéar air chun éifeachtaí marthanacha a tháirgeadh a mhaireann suas le 48 uair an chloig tar éis riarachán amháin. Deir taighdeoirí gur dócha gurb é meicníocht na héifeachta seo ná trí fheabhsú fadtéarmach idir synapses inchinn a chur chun cinn.
Cad é an próiseas taiscéalaíochta feabhsaithe cognaíocha drugaí? Conas a bhíIDRA-21rugadh?
In 1990, neuroscientist Eric Kandel discovered a brain chemical called cyclic adenosine monophosphate response element-binding protein (CREB), which is a key factor in memory formation. In 1994, neuroscientists Tim Tully and Jerry Yin adjusted the way CREB works in a fruit fly. When learning new habits, fruit flies with enhanced CREB were 10 times faster than their unchanged counterparts. Later, other researchers got the same results in mice. In 1999, Qian Zhuo, a neuroscientist at Princeton University, created a mouse with more pairs of NR2B genes, which can coordinate the activity of synaptic receptors in the brain. In memory and learning tests, NR2B enhanced mice performed five times better than unmodified mice. After 2000, many new pharmaceutical companies competed to apply these findings to humans. Both memory pharmaceutical and helikongshan medical are conducting clinical trials of drugs related to CREB. Another COLTEX pharmaceutical company is developing a brain chemical called ampakine to achieve similar effects through another neural pathway. Among so many research institutions, Jingsi pharmaceutical （Abbreviation: IDRA） has developed IDRA-21 through step-by-step analogy research. At the same time, there are many sister products of this product, which have been eliminated for various reasons.